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Mol Neurobiol. :Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage.

2017-05-05 10:43  来源:未知  编辑:高国雷   点击:

Abstract

Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediators, such as Toll-like receptor 4, matrix metalloproteinases, high-mobility group protein box-1, nuclear factor erythroid 2-related factor 2, heme oxygenase, and iron, in secondary injury after ICH and highlights the potential targets for ICH treatment.

KEYWORDS:

Inflammatory mediators; Intracerebral hemorrhage; Microglia


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