中华麻醉在线
您当前位置:主页 > 热点专题 > 中国发表SCI论文汇总 >

J Clin Monit Comput. :Perioperative risk factors and cumulative duration of "triple-low" state associated with worse 30-day mortality of cardiac valvular surgery.

2017-05-05 10:42  来源:未知  编辑:高国雷   点击:

Abstract

ABSRACT:

Hospital stay and mortality in high-risk patients after noncardiac surgery has been associated with a triple low anesthesia. However, the association between anesthesia-related factors and perioperative outcome after cardiac surgery remains unclear.We tested the effect of a novel triple low state: low mean arterial pressure (MAP) <65 mmHg and low bispectral index (BIS) <45 during a low target effect-site concentration (Ce) <1.5 μg ml-1 of propofol anesthesia on postoperative duration of hospitalization and 30-day mortality in cardiac valvular patients. In this prospective observational study, univariable and multivariable logistic regression analyses were used to determine whether perioperative factors, in particular, cumulative duration of triple low state were independently associated with duration of hospitalization and 30-day mortality among patients who underwent elective valvular replacement. 489 patients were included in the final analysis. After adjusting for related covariates, cumulative duration of the triple-low state was not associated with prolonged hospitalization (multivariable odds ratio: 1.007; 95 % confidence interval 0.997-1.017; P = 0.564), but was a significant predictor of 30-day mortality (multivariable odds ratio: 1.016; 95 % confidence interval 1.002-1.031; P = 0.030). Compared to a triple-low duration of <15 min, a duration >60 min increased the 30-day mortality rate by 8 times. After adjusting for patient- and procedure-related characteristics, the cumulative duration of a triple-low state (intraoperative low MAP, low BIS, and low Ce) was associated with poorer 30-day mortality, but not with prolonged duration of hospital stay.The mortality risk was even greater when a cumulative time >60 min.

KEYWORDS:

Bispectral index; Mean arterial pressure; Mortality; Target effect-site concentration


相关推荐
网友评论
请自觉遵守互联网相关的政策法规,严禁发布色情、暴力、反动的言论。
评价:
用户名: 验证码: 点击我更换图片
 
Copyright 中华麻醉在线 All rights reserved
地址:北京市东城区东四西大街42号中华医学会南楼2单元222室麻醉学分会办公室 邮编:100710
联系人:白雪   电话:010-85158614   传真:010-85158753   京ICP备14001125
360网站安全检测平台